Inhibrx is developing a diverse oncology portfolio comprised of therapeutics with distinct mechanisms of action. These include multivalent costimulatory agonists, checkpoint inhibitors and therapeutics to invert the tumor microenvironment toward local immune activation. We also are developing multispecific therapeutics to engage immune cells to directly kill tumor cells.
INBRX-103 (CC-90002) CD47 mAb
Inhibrxâ€™s first immuno-oncology therapeutic is a highly differentiated antibody targeting CD47 that entered clinical studies in early 2015.
INBRX-103 targets CD47 on cancer cells. CD47 binds to SIRPÎ± on macrophages and sends a â€śdonâ€™t eat meâ€ť signal thus protecting cancer cells from being engulfed and eliminated (phagocytosis). Cancer cells utilize CD47 to counter their own surface pro-phagocytic molecules and avoid phagocytosis. INBRX-103 blocks the CD47-SIRPÎ± interaction thereby facilitating efficient phagocytosis and elimination of cancer cells.
Inhibrxâ€™s CD47 antibody could be broadly applicable across all tumor types and has a pre-clinical efficacy and safety profile distinct from other CD47 targeting therapeutics â€“ superior efficacy, no hemagglutination of red blood cells, no platelet or red blood cell depletion and no toxicity observed in high dose primate studies.
This mAb is licensed by Celgene.
INBRX-110 (FPA-154) – GITR mAb
INBRX-110 is a novel, potentially best-in-class engineered GITR antibody with properties aimed at maximizing safety, efficacy and combinability with other therapies. Based on Inhibrxâ€™s multivalent antibody format, this therapeutic is designed to multimerize and activate GITR independent of Fc binding. This is in contrast to conventional GITR antibodies, where efficacy is dependent upon binding and the presence of Fc-receptor bearing cells and may be dampened by competing serum IgG.
This program is licensed by and part of a strategic research collaboration with Five Prime Therapeutics.