Our Pipeline

Currently, four Inhibrx programs are in ongoing clinical trials: three for the treatment of various cancers, and one for Alpha-1 Antitrypsin Deficiency (AATD). Additionally, INBRX-121 is our newest preclinical program currently in cell line development.

The Candidates

Phase 1
Phase 2
Phase 3


Our Recombinant Alpha-1 Anti- trypsin Fc-Fusion Protein (AAT-Fc)

Orphan / Respiratory

INBRX-101 is a recombinant human AAT-Fc fusion protein therapeutic candidate currently being evaluated for the treatment of AATD. Early clinical data has demonstrated a promising pharmacokinetic profile that we believe supports a dosing schedule of every three to four weeks to achieve continuous normal AAT serum concentrations, a significant improvement from patients’ current regimen.

Learn more Phase 1 Trial
Inbrx 101


Our Tetravalent DR5 Agonist


INBRX-109 is a precisely engineered tetravalent sdAb-based therapeutic candidate that agonizes DR5 to induce tumor selective programmed cell death.

Learn more Phase 1 Trial
Inbrx 109


Our Hexavalent OX40 Agonist


INBRX-106 is a hexavalent sdAb-based therapeutic candidate targeting OX40 currently being evaluated in patients with locally advanced or metastatic solid tumors. Signaling through OX40 provides co-stimulation that promotes T-cell expansion, enhanced effector function and memory cell formation, and prevents activation-induced cell death.

Learn more clinicaltrials.gov
Inbrx 106


Our PD-L1 x 4-1BB Tetravalent Conditional Agonist


INBRX-105 is a tetravalent sdAb-based therapeutic candidate currently being evaluated in patients with programmed death ligand 1 (PD-L1) expressing tumors, including those refractory to, or relapsed from, approved checkpoint inhibitor therapies. INBRX-105 is designed to agonize 4-1BB selectively in the presence of PD-L1.

Learn more clinicaltrials.gov
Inbrx 105


Our NKp46 Targeted Detuned IL-2


INBRX-121 is the first program to be borne from our Molecular Targeted Cytokine (MTC) Platform, which combines our sdAb platform with a proprietary detuned cytokine to enable expansion of specific cell populations.

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Inbrx 121

Near-term Clinical Milestones

Inhibrx Clinical Milestones Lg

1. INBRX-101 (AATD) Start to potentially registration-enabling trial

2. INBRX-101 (GvHD) Trial initiations for aGvHD and cGvHD

3. INBRX-105 (PD-L1x41BB) Single agent and Keytruda combination update

4. INBRX-109 (DR5) Initial mesothelioma, Ewing sarcoma, pancreatic cancer, colorectal cancer and GIST combination study data

5. INBRX-121 (IL-2x) IND filing

6. INBRX-106 (OX40) Single agent and Keytruda combination update

7. INBRX-105 (PD-L1x41BB) Possible start to first potentially

8. INBRX-109 (DR5) Potentially registration-enabling Phase 2 Chondrosarcoma data